Lucrezia Borgia was the daughter of Pope Alexander VI and Vannozza dei Cattanei. Her brothers included Cesare Borgia, Giovanni Borgia, and Gioffre Borgia. Her family arranged several marriages for her that advanced their own political position including Giovanni Sforza, Alfonso of Aragon, and Alfonso I d'Este. Tradition has it that Alfonso of Aragon was an illegitimate son of the King of Naples and that her brother Cesare may have had him murdered after his political value waned. Rumors about her and her family cast Lucrezia as a femme fatale, a role in which she has been portrayed in many artworks, novels and films.

https://en.wikipedia.org/wiki/Lucrezia_Borgia